Newport, Wales, United Kingdom - 18 August 2005 - Surface Technology Systems plc (STS) (LSE: SRTS), a leader in plasma process technologies for the growing MEMS and related markets, today announced that it has received an order for its new Pegasus Deep Reactive Ion Etch system from leading automotive MEMS device manufacturer, Robert Bosch GmbH. The order from Bosch strengthens STS' long-standing relationship with the German company, and is the fifth such order since Pegasus was launched on June 28 2005.
The Pegasus system will be installed at Bosch's MEMS wafer fab in Reutlingen, Germany. It will be utilised in a number of research and development projects to develop new MEMS devices.
The flexibility of the STS software with direct manual control of the system enables manufacturers such as Bosch to fully optimize their individual processes, ensuring product quality and high yield. In the MEMS market, where device designs often differ significantly from one manufacturer to another, STS believes its equipment has the capability to meet the demands of a wide range of customers - from 'blue-sky' researchers to high volume manufacturers such as Bosch.
In addition to the process advantages offered by the Pegasus technology, a key factor in gaining this latest order from Bosch was STS' commitment to providing outstanding customer support and service within the German territory. Earlier this year STS strengthened its team at the German Sales Office in Ulm with the recent appointment of a Regional Customer Support Manager, who will work closely with customers in the region.
"The order from Bosch for the Pegasus system is significant news for STS," said Mutsuo Mukuda, Vice Chairman of STS. "Not only have we placed Pegasus with one of our largest and most prestigious European clients, but the sale also reinforces the belief that we have in Pegasus. The range of enhancements and developments that Pegasus brings to the MEMS market, such as the high uniformity plasma source, result in higher etch rates and improved etch uniformity, leading to higher throughput and device yield. We fully expect Pegasus to gain further traction in the MEMS market."
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[Biochemistry and Molecular Biology] Curcumin Modulates SDF-1{alpha}/CXCR4-Induced Migration of Human Retinal Endothelial Cells (HRECs) |
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purpose. The stromal-derived factor (SDF)-1 and the CXC receptor (CXCR)-4 jointly regulate the trafficking of various cell types and play a pivotal role in cell migration, proliferation, and survival. The purpose of this study was to assess whether curcumin inhibits human retinal endothelial cell (HREC) migration by interfering with SDF-1/CXCR4 signaling.
methods. Primary HREC culture was established and maintained in endothelial growth medium. The viability and proliferation of HRECs were assessed by MTT and thymidine uptake assays, respectively. The effect of SDF-1–induced HREC migration (chemotaxis) in the presence and absence of curcumin was determined using the Boyden chamber migration assay. Intracellular Ca2+ concentration was measured by fluorometric analysis. Immunofluorescence and Western blot analyses were performed to quantify CXCR4, phosphorylated AKT, and PI3-kinase expression levels.
results. HREC migration increased in a dose-dependent manner (1, 10, 50, and 100 ng/mL; P < 0.001) in SDF-1–treated cells. In contrast, AMD3100, an inhibitor of CXCR4 effectively inhibited HREC migration dose dependently. HREC migration was decreased when the cells were exposed to EGTA, a chelator of Ca2+. Curcumin also blocked Ca2+ influx, an important signal for HREC migration. In addition, curcumin significantly (P < 0.001) decreased SDF-1–induced HRECs migration and downregulated SDF-1–induced expression of CXCR4, phospho-AKT, phospho-phosphatidylinositol-3-kinase (PI3-K), and eNOS.
conclusions. This study indicates that curcumin has an inhibitory effect on SDF-1–induced HREC migration. The plausible mechanism of action could be upstream blockage of Ca2+ influx and the downstream reduction of PI3-K/AKT signals.
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Chromosomal Laboratories Appoints R. Vincent Miller, Ph.D., Vice President And Chief Technical Officer |
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UCLA Center to Present World Festival of Sacred Music |
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For 16 days in September, the 2008 World Festival of Sacred Music - Los Angeles will present nearly a thousand artists performing in 41 sacred events of music and movement throughout Los Angeles, crossing neighborhoods and cultural, religious and ideological boundaries in the spirit of peace. |
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Properties of Zinc Releasing Surfaces for Clinical Applications |
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Two series of glasses of general formula (2-p) SiO2·1.1Na 2O·CaO·pP2O5·xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when cultured on them. The resulted good cell adhesion and growth, along with nonsignificant changes of the focal contacts, allow the authors to indicate HZ5 and HP5Z5 glasses as the ones having optimal ratio of Zn/P to maintain acceptable cell behavior, comparable to the bioactive glass (Bioglass®) used as a control; results are also rationalized by means of three-dimensional models derived by molecular dynamic simulations, with decomposition and conversion rates optimized with respect to the parent Hench's Bioglass®. |
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Heads-up study of hair dynamics may lead to better hair-care products |
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rom frizzy perms to over-bleached waves, "bad hair days" could soon become a less frequent occurrence. Chemists report the first detailed microscopic analysis of what happens to individual hair fibers when they interact with each other, an advance in knowledge key to the development of improved shampoos, conditioners, and other products for repairing damaged hair, the researchers say. (2008-08-18) |
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